Possible Role of Adrenomedullin In the Pathogenesis of Tubal Ectopic Pregnancy

A recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM) shows that the hormone adrenomedullin (ADM) may help predict ectopic pregnancy.

“This is the first report to address the effect of ADM on cilia beat frequency and muscular contraction in the oviduct,” says the lead author of this study, Wai-Sum O, PhD, of the University of Hong Kong. “We found that low ADM expression may contribute to slower muscle contraction and ciliary beating, which hampers embryo transport and favors embryo retention in the oviduct. This finding is significant because plasma ADM levels may be useful in predicting TEP.”


Departments of Anatomy (S.B.L., W.S.O.), Obstetrics and Gynecology (H.W.R.L., W.S.B.Y., E.H.Y.N.), Medicine (J.C.H.), Pathology (A.N.Y.C.), Department of Physiology (F.T.), Centre of Reproduction, Development, and Growth (W.S.B.Y., E.H.Y.N., W.S.O.), and Centre of Heart, Brain, and Healthy Ageing (F.T.), The University of Hong Kong, Hong Kong.