Unless an ectopic pregnancy is visible by ultrasound, diagnosis can be a challenge. Differentiating ectopic pregnancies from intrauterine pregnancies can be impossible without intervention or follow-up. This poses a clinical dilemma to the practitioner given the inherent danger to the mother of tubal rupture of an ectopic pregnancy versus the fear of intervening in the case of a desired pregnancy without certainty of diagnosis. Early diagnostic modalities are clearly lacking, and serum biomarkers are currently being investigated as a solution to need for a rapid and accurate test for ectopic pregnancy.
Clinical Obstetrics & Gynecology:
June 2012 – Volume 55 – Issue 2 – p 418–423
Serum Biomarkers for Detecting Ectopic Pregnancy
RAUSCH, MARY E. MD, MSCE*; BARNHART, KURT T. MD, MSCE†