By registering on our forum, you can view and contribute to more topics on ectopic pregnancy. Your details are confidential and we do not send unsolicited emails. For your confidentiality, you can choose your own forum name to protect your anonymity if you so wish. If you register, there is no obligation to post; you can simply take comfort from the words of others. It is entirely up to you whether you post a message or read others' experiences or do both.

How do people feel after methotrexate? Thank you!

This is a welcoming place for you to ask your questions and share your knowledge and experiences of ectopic pregnancy.

Moderators: EPT Host 9, Information@ectopic, EPT Host 8, EPT host 6, EPT Host 11, EPT Host 5, EPT Host 4, EPT Host 2, Feedback@ectopic, epthostseven, EPT Host 3, EPT Host 10

How do people feel after methotrexate? Thank you!

Postby Aoife » Tue Sep 17, 2019 11:50 am

Hi everyone, I am new to this forum and thank you it’s really helpful as I don’t know anyone else who has gone through an ectopic pregnancy. This is my first pregnancy and it was diagnosed ectopic (in my left ovary) this day last week. As my levels were quite low (349) at my first bloods we were hoping they might decrease on their own because I have been bleeding for two weeks now. I was an inpatient so they could monitor the levels closely and had concerns about rupture. Unfortunately the levels remained static (but n pain which was good) so I had the methotrexate injection yesterday evening! I really hope it works and I don’t need to have surgery or another injection. I’m just wondering how people felt in the first few days? The bleeding doesn’t seem to be getting any heavier/cramps are not that bad! Just worried maybe it’s not working or does it take a few days to kick in? Sorry I should have asked the docs all these questions but I found being in the hospital very upsetting and no one was particularly helpful unfortunately. Thanks so much ! X
Posts: 7
Joined: Mon Sep 16, 2019 8:14 pm

Re: How do people feel after methotrexate? Thank you!

Postby EPT Host 20 » Wed Sep 18, 2019 7:47 pm

Dear Aoife,
I am so sorry to hear of your ectopic pregnancy and loss. Do not apologise for asking questions here. The boards are a safe place to ask any questions, share feelings or even just to vent.
The action of Methotrexate is not instantaneous, and your doctors are looking to see a drop in your hCG value of at least 15% between days four and seven.
I too had methotrexate, my bleeding and abdominal pain worsened around day four after the injection and I was shocked by how exhausted I felt, but this was all normal.
We advise that you do not do any heavy lifting or strenuous exercise whilst your levels are reducing as sadly there is still a risk of rupture with lowering levels of hCG. Therefore, if you experience any severe pain or bleeding, please contact your local EPU or seek urgent medical advice.
We have more information about methotrexate injection here-

I am afraid it is difficult to predict how long it will take for your hormone levels reach non-pregnant levels. As we are all individual, our bodies respond differently to the drug and it depends on factors like how high levels reached and our unique physiology. What I can say is that it can take a number of weeks and, while it can take some time, it is not as invasive a procedure as surgery. Also, in terms of chances of future successful pregnancies, studies do not show a significant difference between treatment routes, whether surgical, medical using methotrexate or expectant management (allowing time for the body to resolve the pregnancy itself).

Take things easy, allow time to grieve, to heal both physically and emotionally. We will be here for you for as long as you need,
Sending much love,
Karen x
The Ectopic Pregnancy Trust
Registered Charity Number: 1071811

If we have been able to help you, are you able to help us with a small donation or by volunteering or fundraising?
Further information is available at
Email us:
We provide a call-back helpline service: 020 7733 2653
The latest EPT newsletter is out now! You can take a look at the Winter edition and subscribe to our mailing list here:
Detailed medical information can be found on our website. Please remember online medical information is NO SUBSTITUTE for expert medical advice from your own health care team
EPT Host 20
Posts: 1482
Joined: Thu May 31, 2012 9:58 pm

Re: How do people feel after methotrexate? Thank you!

Postby Aoife » Wed Sep 18, 2019 8:23 pm

Hi Karen,

Thanks so much for getting back to me, I really appreciate it! I wasn’t sure what to expect so that is really helpful to know. Hopefully they will continue to drop! Thanks again xx
Posts: 7
Joined: Mon Sep 16, 2019 8:14 pm

Re: How do people feel after methotrexate? Thank you!

Postby portland24 » Fri Sep 20, 2019 6:17 am

Good luck I hope it works.

There is a list of side effects here:

I just received my second methotrexate injection yesterday. This is my second ectopic after a salpingostomy this spring. After reading multiple forums, it seems like everyone varies in their response. Some people experience very mild side effects and can return activities of daily living and work immediately.

Personally, it hit me pretty hard. The most debilitating symptoms were fatigue, nausea, and abdominal pain. I took all of last week off of work and am taking this next week off of work as well.

Hopefully your side effects are minimal!
Posts: 8
Joined: Tue May 21, 2019 6:24 am

Re: How do people feel after methotrexate? Thank you!

Postby Aoife » Fri Sep 20, 2019 4:03 pm

Hi Portland 24,

Thank you so much for getting back to me! I’m really sorry to hear you have been through all of that, I really hope you are doing ok. You are so right to take the time off work. Yesterday I was in agony with the pains in my left side but they are less extreme today! I am absolutely exhausted too! I went in for my day 4 bloods and they have remained static still.... was really hoping they might decrease. What had your day 4 bloods said? I really hope this second dose works for you!
Posts: 7
Joined: Mon Sep 16, 2019 8:14 pm

Re: How do people feel after methotrexate? Thank you!

Postby portland24 » Sat Sep 21, 2019 4:25 am

My hcg has also remained relatively static with only minor fluctuations, up and down.

First methotrexate: 305
day 4 356
day 7 426

second methotrexate (a day after day 7 lab): 340

I'll get my "second" day 4 labs drawn tomorrow. If there is a slight increase in my hcg I am not going to read into it too much because that happens. Hopefully it will decrease by more than 15% by day 7.

I'm glad your pain has decreased somewhat. Thinking positively about your numbers, this process is crappy enough as it is! So much anxiety with waiting, and the symptoms are so uncomfortable.
Posts: 8
Joined: Tue May 21, 2019 6:24 am

Re: How do people feel after methotrexate? Thank you!

Postby Aoife » Sat Sep 21, 2019 2:23 pm

Thanks so much for getting back to me! Yeah mine are similar numbers to you!

Best of luck with this injection, really hope it goes well for you. I know it’s the waiting that’s such a killer !! Finding the whole process really emotionally draining.. I’ve just set up my own business too so it’s hard to take time off etc but I think I might have to again this week if I’m getting the second injection. Take care, wishing you the best of luck with it all xx
Posts: 7
Joined: Mon Sep 16, 2019 8:14 pm

Return to Main Board

Who is online

Users browsing this forum: No registered users and 8 guests

Medical advice disclaimer

Online medical advice should never be considered a reliable alternative to personal health care. If you have concerns or need advice on a specific problem, please refer to your own doctor and do not wait for a reply from our staff. If you wish to contact the Ectopic Pregnancy Trust direct, email


If we have helped you, could you help us with a small donation? We receive no government funding and rely completely on third party fundraising. Every little helps to keep us here for the people who need us.

The Etopic newsletter

Sent quarterly, Etopic is The Ectopic Pregnancy Trust's regular e-newsletter, with insights into the work we do, the charity's activities and how we provide support, raise awareness and support research into ectopic pregnancy.

Read our latest newsletter »