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Suppressed immune system and COVID

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Posts: 42
Joined: Thu Dec 03, 2020 11:13 am

Suppressed immune system and COVID

Post by LauraG »

Hi all,

I'm not sure if anyone can help but thought it was worth asking.

I was given 2 doses of methotrexate at the end of Nov/beginning of December.
I was told this would suppress my immune system and to be very careful re COVID. I work at a school so the doctor said I needed to stay off work and basically sheild at home.
Unfortunately, the methotrexate didn't work and I had surgery on the 6th Dec. I was told when I was discharged to be extra careful as my immune system would be suppressed and I'd be vulnerable whilst I was healing.

Does anyone know how long my immune system would be suppressed for? I've asked my GP and they said they don't know. Work have been amazing and as we are technically shut I've been able to work from home but if staff need to isolate I may be needed to go in. I'm not sure if I'm worrying unnecessarily but no one seems to be able to give me a definite answer.

Thanks xx

EPT Host 20
Posts: 2078
Joined: Thu May 31, 2012 9:58 pm

Re: Suppressed immune system and COVID

Post by EPT Host 20 »

Dear LauraG,
I am so sorry to hear of your ectopic pregnancy and loss,
Unfortunately I am not medically trained so cannot give you specific answers to your questions. We do however have information on our website which I have copied for you

Methotrexate is an immunosuppressant when used for a long time to treat auto-immune diseases and skin conditions. The methotrexate regimen used for ectopic pregnancy is different; it is given in a maximum of two one-off doses to women with healthy immune systems and normal white cell counts. White blood cells fight infections. Very rarely, methotrexate causes the white cell count to fall and if this happens it could potentially impact their immune systems. In our medical advisers’ experience, this side effect is very rare and should neither prevent methotrexate being used, nor prompt women to routinely shield after having methotrexate.

According to the RCOG:
“It is likely the detrimental effects of methotrexate in COVID-19 are minimal in well women. Methotrexate is a mildly immunosuppressive medication but there is not thought to be a significant risk at the dose used to treat ectopic pregnancy. It is unlikely to increase vulnerability to COVID-19 and does not require home shielding after administration.”

We have more information on coronavirus and ectopic pregnancy on our website here- ... ronavirus/

Sending much love,
Karen x

The Ectopic Pregnancy Trust
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Posts: 42
Joined: Thu Dec 03, 2020 11:13 am

Re: Suppressed immune system and COVID

Post by LauraG »

Thank you so much. Xx

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